Leukocytic Inclusions—Döhle Bodies—Associated with Platelet Abnormality (The May-Hegglin Anomaly)
نویسندگان
چکیده
منابع مشابه
The May-Hegglin anomaly: platelet function, ultrastructure and chromosome studies.
T HE MAY-HEGCLIN ANOMALY is a rare hereditary condition characterized by giant platelets and D#{246}hle inclusion bodies in the granulocytes. May first described the anomaly in 1909,’ and in 1945 Hegglin described the condition in a man and his two sons.2 Subsequent reports have confirmed the familial nature with an autosomal dominant mode of inheritance.3 3 Although most persons with the May-H...
متن کاملPlatelet membrane studies in the May-Hegglin anomaly.
Since studies of the giant platelets in the Bernard-Soulier syndrome have shown decreased electrophoretic mobility, decreased sialic acid, and an abnormality in a membrane glycoprotein, we performed similar studies on the giant platelets from two patients with the May-Hegglin anomaly. The patients' platelet electrophoretic mobilities did not differ from control. Although the total sialic acid c...
متن کاملMay-Hegglin anomaly.
A 35-year-old woman with known May-Hegglin anomaly (and a positive family history) was seen in a fertility clinic. She was found to have marked thrombocytopenia (16 109/L). The other cell counts were normal. Other than hypothyroidism that was controlled with levothyroxine, she was otherwise healthy with no evidence of bleeding. The peripheral blood film demonstrated the features of May-Hegglin ...
متن کاملUltrastructural Studies of the May-Hegglin Anomaly
By S. W. JORDAN AND \V. E. LARSEN I HE INHERITED CONDITION known as the May-Hegghin anomaly is characterized by the occurrence of crescent or spindle-shaped cytoplasmic inclusions containing ribose nucleic acid ( RNA ) in polymorphonuclear leukocytes in combination with platelet abnormalities. May ( 1909) 1 noted the presence of distinctive basophilic, pyroninophilic patches in the cytoplasm of...
متن کاملUltrastructure of the May-Hegglin anomaly.
Ultrastructural features of the leucocytes in two patients suffering from the May-Hegglin anomaly were studied using electron microscopy. In both the cases, electron dense material parallel to the long axis of the inclusions were noted. Platelet ultrastructure was normal. A review of the literature indicates that the May-Hegglin anomaly is a heterogeneous condition both ultrastructurally and cl...
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ژورنال
عنوان ژورنال: Blood
سال: 1962
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v20.6.657.657